Mazatec Shamans are known for their cultivation and spiritual use of the plant salvia divinorum, morning glory seeds and psilocybe mushrooms.

One of the best known of the Mazatec Shamans would be Maria Sabina.

There is little information concerning the Mazatec people generally before the arrival of the Spanish and less concerning their spiritual practices.

Several researchers have commented on the difficulty in obtaining information, as the Mazatec shamans tend to be secretive and protective of their practices.

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